Abstract
P 037
Clinical long-term treatment with an amniotic membrane carrier
Constantin E. Uhlig, Holger Busse
Klinik und Poliklinik für Augenheilkunde, Universitätsklinikum Münster, Münster
Objective
The amniotic membrane carrier that had been developed in our hospital was clinically tested and side effects documented.
Methods
A 27-year old patient had suffered an itching of his ocular surface, degree III (Rooper-Hall), with hypochlorid-solution. Visual acuity measured with Snellen letters was 0.4 and lid anatomy regular. Treatment was performed with an amniotic membrane carrier and cryofixated amniotic membranes that were fixated to the carrier with 10.0 nylon. The hybrid was layed into the fornix and the amniotic membranes exchanged every seven days. Continuous treatment was 28 days. Local treatment was ofloxacine 4x/d, dexamethasone-21-(3-sulfobenzoat) 5x/d and hyaluronic acid 3x/d. Investigations included slit-lamp examinations of the anterior segment and funduscopy every seven days, at the 28th treatment day, and three months later.
Results
The application of the hybrid into the fornix presented simple, atraumatic and without any harm to the patient. The hybrid was mobil like a contact-lens, and its local stability sufficient. Formerly complaints, such as grittiness, stopped at the first day of treatment. When the membranes were exchanged, one was centrally ruptured, and three were complete. On the 28th treatment day, the corneal epithelium was completely closed and the conjunctival and limbal area obviously more regular than at the beginning. Local or systemic side effects were not observed. Visual acuity was 0.5 and increased to 1.0 during the following three months.
Conclusions
The amniotic membrane carrier combined with an amniotic membrane seems to be comfortable even during long-time wearing and might be a valuable alternative treatment procedure compared to suture fixated overlay membranes (3). Further studies are initiated to investigate different sized membrane carriers to be used in patients with various ocular axial length and lid anatomies.
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