Abstract
P 042
Proton beam irradiation of choroidal melanoma with extensive extraocular growth
Shideh Faramarzi1, Yaroslava Chopovska1, Werner Schmidt1, Gregor Willerding2, Lothar Krause2, Michael H. Foerster2
1Klinik und Poliklinik für Augenheilkunde, Standort Gießen, Universitätsklinikum Gießen und Marburg GmbH, Gießen, 2Augenklinik, Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin, Berlin
Objective
The bulb preserving therapy of choroidal melanoma with orbital extension presents a challenge. The eye and vision sparing potential of proton beam irradiation is demonstrated in this case report.
Methods
A 71-year-old male patient presented with an increasing loss of visual acuity in his left eye. Ophthalmoscopy showed a choroidal melanoma with serous retinal detachment in the lower nasal quadrant. The best corrected visual acuity was 0.5. The ultrasonography gave evidence of extraocular growth with a maximal extension of 10.2 mm whereas the maximal height of the intraocular tumour was 3 mm. A distant metastasis was excluded. A 68 MeV proton irradiation was performed with a total dose of 60 CGE , delivered in four after MRI-based treatment planning.
Results
Within one year after the radiation treatment the intraocular tumour height decreased to 2.5 mm whereas the extraocular component regressed to 7.5 mm. The serous retinal detachment resolved completely and best corrected visual acuity remained 0.5.
Conclusions
Within a one-year follow-up proton beam irradiation showed the feasibility of preserving eye and vision in this case.
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