Abstract

P 127

Comparison between parapapillary fundus autofluorescence analysis using fundus photography and scanning laser ophthalmoscopy

Ricarda Wienrich, Arne Viestenz, Achim Langenbucher, Wolfgang Behrens-Baumann
Universitäts-Augenklinik, Otto-von-Guericke-Universität, Magdeburg

Objective
The parapapillary autofluorescence (PAF) at zone beta is an indicator for detection of manifest or early glaucomatous optic neuropathy. Because all studies, which have been performed until now, are based on a scanning laser ophthalmoscope (HRA), the PAF was investigated using a fundus camera with autofluorescence mode to evaluate clinical alternatives (light photograph vs. laser scanning technique).
Methods
Controlled, prospective cross sectional study on 130 consecutive eyes. Eyes of healthy subjects as well as eyes with retinal and papillary pathologies were investigated with HRA II (Heidelberg Retina Angiograph II, 3 series, 9 images each, one mean image) and a fundus camera (Zeiss FF 450 Plus). The minimal visual acuity was 20/60. A 30° large parapapillary zone was investigated using both diagnostic devices. The measurement of PAF was performed with the software Heidelberg Eye Explorer (HRA), and the planimetric software Chili (fundus photographs). Two experienced ophthalmologists analysed the PAF.
Results
A pronounced fundus autofluorescence was detected in 99 of 130 eyes with the HRA (76%) and in 117 eyes (90%) with fundus photography. Fundus autofluorescence was visible with both imaging techniques in 89 eyes only. A PAF was found with HRA in 86 of the 99 eyes with fundus autofluorescence (87%) and in 84 of 117 eyes using fundus photography (72%). Analysing the 89 eyes with a pronounced autofluorescence in both imaging techniques, a measurable PAF was detected in 89% with HRA (79 eyes) and only in 77.5% (69 eyes) with fundus photography.
Conclusions
Scanning laser ophthalmoscopy is superior to the conventional fundus photography to detect the PAF. However, the autofluorescence fundus photography seems to be a diagnostic alternative in PAF analysis.

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