Abstract

P 135

Expression of Aquaporin 1 in human lens epithelium in complicated cataract after trabeculectomy

Yang Yang1,2, Xiongwu Zhou1, Guigang Li1, Hong Zhang1
1Department of Ophthalmology, Tongji Hospital of Tongji Medical College of Huangzhong University of Science & Technology, Tongji Hospital of Tongji Medical College of Huangzhong University of Science & Technology, 2Augenklinik LMU München, München, Deutschland

Objective
To investigate the effect of aquaporin 1 (AQP1) in complicated cararact after trabeculectomy.
Methods
Thirty-eight specimens of anterior lens capsules composing of 20 eyes with age-related cataracts, 10 eyes with complicated cataract after trabeculectomy and 8 eyes with glaucoma without cataract were obtained by phacoemulsification and intraocular lens implantation. Immunohistochemical techniques were processed in all specimens to localize the expression of AQP1. Computer-imaging analysis was performed to quantitatively compare the expression of AQP1 in each group.
Results
AQP1 was found in lens epithelium in all specimens. Compared with patients with glaucoma, the expression of AQP1 decreased in patients with complicated cataract after trabeculectomy and in patients with age-related cataract. Statistically significant difference was showed between patients with complicated cataract after trabeculectomy and the patients with glaucoma (P < 0.05). No statistically significant difference was showed between patients with complicated cataract after trabeculectomy and the patients with age-related cataract (P = 0.232).
Conclusions
AQP1 may play a role in the occurrence and development of cataract after trabeculectomy, as in age-related cataract formation.

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