Abstract

P 220

Elevated platelet derived growth factor-BB levels in aqueous humor of patients with acute anterior uveitis

Salvador Garcia-Delpech1, Stephanie Rohrweck1, Manuel Díaz-Llopis1, David Salom1, Patricia Udaondo1, Maria Garcia-Pous2, Ana Marina Suelves1
1Oftalmología, Hospital Universitario La Fe, Valencia, Spain, 2Oftalmología, Hospital General Universitario, Valencia, Spain

Objective
Platelet-derived growth factor-BB (PDGF-BB) is one of the various growth factors of the PDGF-family, which has an important chemotactic activity in inflammatory diseases.
The objective of this study was to evaluate, if there are any alterations of the levels of PDGF-BB in the aqueous humor in patients with acute anterior uveitis (AAU).
Methods
A prospective, comparative control study. Aqueous humor was collected from 16 eyes of 16 patients with AAU. The level of PDGF-BB was determined with a commercially available enzyme-linked immune-absorbent assay kit. The control group comprised 16 aqueous samples from 16 eyes about to undergo cataract surgery and without any other ocular or systemic diseases.
Results
In patients with UUA, the concentration of PDGF-BB in aqueous humor was markedly higher than in control subjects (Mann-Whitney U test, p<0,001). We measured levels of 5,65 pg/ml ± 2,58 pg/ml (mean ± SD) in eyes with UUA versus 2,82 pg/ml ± 0,65 pg/ml in the eyes without inflammatory disease.
Conclusions
In eyes with AAU the aqueous humor PDGF-BB level was increased in our study. This result indicates an association of PDGF-BB with the regulation of inflammation in patients with AAU.

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