Abstract

P 285

Long-term results of Bevacizumab therapy for perifoveal retinal telangiectasis.

Kouris Ninios, Ursula Löw, Susanne Goebels, Georgia Milioti, Stefan Hoffmann, Berthold Seitz
Klinik für Augenheilkunde, Universitätskliniken des Saarlandes, Homburg/Saar

Objective
Perifoveal telangiectasis (PT), also known as idiopathic juxtafoveolar retinal telangiectasis Type 2, presents areas of capillary telangiectasis involving mostly the temporal half of the fovea. Treatments with laser photocoagulation, photodynamic therapy (PDT) or intravitreal injection of triamcinolone are unsatisfying. We report about the 12-month findings of a patient with PT without subretinal neovascularisation (NV) following intravitreal bevacizumab therapy (IVB).
Methods
The worse eye of a 55-year-old male patient with bilateral PT without NV received monthly four IVB of 2.5 mg. Within a follow-up period of 12 months, 2 combined injections of Bevacizumab and Triamcinolone Acetate, a Ranibizumab injection and a PDT were performed depending on the disease activity. The other eye was not treated, given a visual acuity of 1.0. Best corrected visual acuity (BCVA), funduscopy, fluorescein angiography (FLA) and measurements of the retinal thickness with optic coherence tomography (OCT) were performed.
Results
BCVA increased from 0.2 at baseline to 0.5 one month following the forth IVB. FLA demonstrated almost absence of leakage and OCT a reduction of retinal thickness from 321 µm at baseline to 257 µm. After 5 months BCVA decreased slightly to 0.4 and a rebound effect of leakage and macular edema (retinal thickness: 300 µm) was observed. Further therapies failed to recover leakage and macular edema. At 12 months BCVA, FLA and OCT did not differ from baseline.
Conclusions
In contrast to PT with NV there has been no effective treatment for PT without NV, because of the idiopathic capillary diffusion abnormalities of the latter. In analogy with other treatments, the long-term success of anti-VEGF therapy seems to be uncertain in these cases.

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