Abstract

P 286

Detection of macular pigment – A comparison of two methods

Jens Dawczynski1, Susanne Jentsch1, Dietrich Schweitzer1, Martin Hammer1, Jürgen Strobel1, Ute Wolf-Schnurbusch2, Sebastian Wolf2
1Klinik für Augenheilkunde, Universitätsklinikum Jena, Jena, 2Universitäts-Augenklinik, Inselspital Bern, Bern, Schweiz

Introduction
For a better comparison of macular pigment measuring results a direct comparison of two methods (1-wavelength reflection method and 2-wavelength auto-fluorescence method) was performed.
Methods
39 eyes of 39 patients (age 20 to 87 years; group 1: 20 to 44 years; Group 2: 65 to 87 years) macular pigment was measured by two different methods. Measurements by the 1-wavelength reflection method was performed with VISUCAM NM/FA® fundus camera (Carl Zeiss Meditec AG, Jena) with a 5 mega pixel color CCD chip as detector. 2-wavelength auto-fluorescence measurements have been performed by 2-wavelength auto-fluorescence laser scanning ophthalmoscope (modified HRA, Heidelberg Engineering, Heidelberg).
Results
For a direct comparison of methods patients were divided in group 1 (younger patients <45 years, n=20) and group 2 (elderly patients >65 years, n=19) with partly significant cataract. A high significant correlation was found between 1-wavelength reflection method and the 2-wavelength auto-fluorescence method for group 1 (R2=0.92). For elderly patients (group 2) correlation of results was R2=0.86.
Discussion
Both methods (1-wavelength reflection method and the 2-wavelength auto-fluorescence method) are appropriate for objective measurement of macular pigment. Both methods show both in younger and in elderly patients a significant correlation of results.

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