Abstract

DO.08.05

Intraocular lymphoma with iris involvement

Stefan Kreis1, Mete Gök2, Harun Akgül2, Michael Freistühler2, Norbert Bornfeld2
1Recklinghausen, 2Zentrum für Augenheilkunde, Universitätsklinikum Essen, Essen

Objective
Intraocular Non-Hodgkin´s Lymphomas can occur as a primary tumor or as secondary metastasis from systemic disease. In contrast to retinal and choroidal lymphomas there are less published reports on iris lymphoma and iris involvement.
In the following we would like to present two cases of intraocular lymphomas with pathologically proved iris involvement.
Methods
Case 1: A 70-year-old woman with a known systemic Non-Hodgkin lymphoma presented with an amelanotic iris tumor of the left eye. An iris biopsy was performed.
Case 2: A 42-year-old patient presented with iris tumor and pseudohypopyon. The patient underwent an iris biopsy and anterior chamber aspirate.
Results
Case 1: The molecular pathologic result showed a manifestation of lymphoma within the iris basis. The patient underwent treatment with brachytherapy (Ruthenium applicator). After developing an ocular relapse external beam irradiation followed.
Case 2: Both in the iris biopsy and in the anterior chamber aspirate a Non-Hodgkin B-cell-lymphoma could be shown. The patient underwent chemotherapy. Because of a progression of the tumor external beam irradiation followed. During further systemic examination a manifestation of abdominal lymphoma was detected.
Conclusions
Concerning amelanotic iris tumors of unknown origin as well as inflammation-like processes as a part of a mascerade-syndrome it is important to think of possible manifestation of lymphoma. A diagnostic biopsy and an anterior chamber aspirate often helps to lead to a definitive diagnosis and to provide further diagnostic and prognostic information.

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