Abstract

FR.21.04

Development of retinal and subretinal compartments in monthly and quarterly anti-VEGF therapy using spectral-domain optical coherence tomography

Isabelle Golbaz, Christian Ahlers, Geraldine Stock, Christopher Schütze, Wolfgang Geitzenauer, Christian Prünte, Ursula Schmidt-Erfurth
Universitätsklinik für Augenheilkunde, Medizinische Universität Wien, Wien, Österreich

Objective
To analyze functional and morphological changes in retinal and subretinal compartments in age-related macular degeneration (AMD) under ranibizumab therapy, using spectral-domain optical coherence tomography (SD-OCT) and manual segmentation software.
Methods
27 patients (27 eyes) with neovascular (n) AMD were examined over a 12-month period. Three different treatment arms of quarterly and monthly intravitreal injections of ranibizumab were performed. Imaging of the macular region was carried out using a Cirrus SD-OCT system. Retinal and subretinal compartments were identified by manual segmentation software in specified B-scans.
Results
SD-OCT and manual segmentation offered a detailed identification of retinal and subretinal compartments and their relation to treatment effects. During loading dose all parameters revealed a positive treatment effect. The retinal area (RA) showed the efficacy of ranibizumab resulting in a significant thinning. The area of subretinal fluid (SRFA) seemed to be a critical factor for identification of disease recurrence in nAMD.
Conclusions
The analysis and exact delineation of different retinal and subretinal compartments in SD-OCT images using appropriate segmentation software systems helps to understand the therapeutic treatment effects of anti-VEGF therapy on the central retina.

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