Abstract

SA.17.03

Therapy option for primary localized orbital lymphomas of low malignity

Kleanthis Manousaridis1, Ria Beck1, Gunther Klautke2, Rudolf Guthoff1
1Universitäts-Augenklinik Rostock, 2Universitätsklinik für Strahlentherapie, Universität Rostock

Objective
Assessment of the efficacy of radiotherapy as first line therapy for the treatment of primary localized orbital lymphomas of low malignity (St IE) based on our cases.
Methods
7 patients (3 female, 4 male, mean age 58,7 years) with histologically proven primary localized orbital lymphomas of low malignity treated with radiotherapy were retrospectively evaluated. 6 patients had a low-malignity MALT-lymphoma and 1 patient had a low malignity lymphoplasmocytic immunocytoma. Bilateral orbital involvement was observed in 2 patients. The dose was 40 Gy for unilateral and 36 Gy for bilateral lymphoma. The follow-up period was 12-24 months.
Results
Complete regression was achieved in 6 patients 12-24 months after radiotherapy. In one patient an increase of tumor mass was observed 3 months after radiotherapy. Chemotherapy was subsequently performed and the patient was free of disease after 2 years. In 2 cases cataract surgery had to be performed for post radiotherapy cataract formation.
Conclusions
The majority of primary localized orbital lymphomas are tumors of low malignity. Radiotherapy is the first line therapy in these cases. Success rates of >90 % are reported in the literature. Relapse occurs generally within a period of 24 months after therapy. For this reason long-term follow-up of these patients is suggested. Complications such as optic neuropathy, radiation retinopathy or cataract formation are to be expected with dose that exceeds 40 Gy.

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