Abstract

SA.17.09

Phospholipid liposomes and hyaluronic acid in the therapy of evaporative dry eye

Karl-Georg Schmidt1, R. Khaireddin2
1Augenklinik Garmisch-Partenkirchen, Augenklinik Starnberg, Starnberg, 2Klinik und Poliklinik für Augenheilkunde, Universitätsklinikum Hamburg-Eppendorf, Hamburg

Objective
Evaporative dry eye is the most common form of tears film dysfunction.
Substitution therapy with a phospholipid-liposomal eye spray (PL-S) and an artificial tear preparation based on hyaluronic acid (Hy-D) were compared.
Methods
218 patients suffering from evaporative dry eye were included in this prospective, randomized multicenter study. Two groups were treated either with PL-S or Hy-D, each for a period of 3 months.
Tests (lid-parallel conjunctival folds (LIPCOF), Non Invasive Break up time (NIBUT), Schirmer’s Test, inspection of lids and subjective assessment) were performed before as well as 4 and 12 weeks after initiation of this study.
Results
On therapy, parameters investigated improved in both groups, with greater improvements in the PL-S group, particularly regarding the degree of inflammation of the lid margins as well as the grade of LIPCOF. When compared to Hy-D, NIBUT more than doubled in the PL-S – group.
Conclusions
Both therapies improved evaporative dry eye, but patients on phospholipid-liposomal eye spray demonstrated greater clinical benefit from their therapy.

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