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AbstractSO.09.08 Hydrophilic vitreous substitute – the future? Peter Szurman, Charlotte Frank, Martin S. Spitzer The natural vitreous is a highly hydrated fibrillary composite with unique biophysical properties. Since more than 100 years considerable efforts have been made to develop an artificial vitreous substitute. But since today no ideal tamponade material has been available yet. The main desired properties comprise a sufficient tamponade effect without buoyancy, advantageous rheological parameters in view of viscosity, pseudoplasticity, cohesiveness, transparency and refraction stability, a good biocompatibility and biodegradability, shock absorption, no proliferation scaffold and potentially serving as a slow release system for antiproliferative drugs. Current tamponade materials fulfill these demands only in part by following a different strategy compared to the effect of the natural vitreous. They rather act by surface tension and buoyancy. One should take into account that both properties do not represent the biomechanical action of the natural vitreous. Current research strategies rather follow the concept to mimic the properties of the natural vitreous by developing hydrogel polymers as vitreous substitute. The first prototypes of these hydrogels seem to achieve these desired properties indicating that this might be a future strategy in retinal detachment surgery. |
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