Abstract

SO.16.07

Comparison of retrobulbar hemodynamics between normal tension glaucoma and anterior ischemic optic neuropathy

Andreas Remky1, Marion Kaup2, K. Oliver Arend3, Niklas Plange4
1Augenbelegklinik im KH Barmherzige Brüder, Regensburg; 2Universitätsklinikum der RWTH Aachen, Kantonsspital St. Gallen; 3Augenzentum Alsdorf; 4Augenklinik, Universitätsklinikum Aachen

Objective
To compare flow velocities of the retrobulbar vessels in chronic vascular neuropathy in normal tension glaucoma (NTG) to those of acute circulatory disorder of anterior ischemic optic neuropathy (AION).
Methods
Fourty-six patients with NTG (mean age: 66 ± 9 ys) and 46 patients with AION (mean age: 68 ± 9 ys) were included in the study. Blood flow velocities (peak systolic velocity PSV and end–diastolic velocity EDV) and resistive indices of the ophthalmic artery (OA), central retinal artery (CRA) and nasal and temporal posterior ciliary arteries were measured by means of colour Doppler imaging (CDI).
Results
No differences were detected for heart rate, diastolic arterial pressure and IOP between the two groups. In AION patients systolic arterial blood pressure was signifi cantly higher compared to the NTG group (148 ± 26 mm Hg vs. 131 ± 18 mmHg, p = 0.0004). CDI revealed significant differences of the resistive index of the OA (RI AION: 0.80 ± 0.06; NTG: 0.76 ± 0.07). Furthermore, PSV in OA was correlated to systolic blood pressure in NTG (r = 0,4), but not in AION (r = -0.01). In AION, PSV of CRA was significantly lower compared to NTG (AION: 7.2 ± 1.9 cm/s; NTG 8.0 ± 1.6 cm/s).
Conclusions
The chronic vascular deficiency in NTG seems to be similar to that of the acute circulatory breakdown in AION. In both vascular disorders of the optic nerve only small differences of flow velocities may be detected by CDI.

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